Jim Simons's position in Astrazeneca plc - ADR is currently worth $50.5 Million. That's 0.08% of their equity portfolio (301st largest holding). The first Astrazeneca plc - ADR trade was made in Q2 2013. Since then Jim Simons bought shares eighteen more times and sold shares on 24 occasions. The stake costed the investor $38.4 Million, netting the investor a gain of 31% so far.