Jim Simons's position in United Therapeutics is currently worth $516 Million. That's 0.80% of their equity portfolio (11th largest holding). The investor owns 4.63% of the outstanding United Therapeutics stock. The first United Therapeutics trade was made in Q2 2013. Since then Jim Simons bought shares 22 more times and sold shares on twenty occasions. The stake costed the investor $251 Million, netting the investor a gain of 106% so far.