Jim Simons's position in Ionis Pharmaceuticals is currently worth $4.6 Million. That's 0.01% of their equity portfolio (1336th largest holding). The first Ionis Pharmaceuticals trade was made in Q4 2015. Since then Jim Simons bought shares thirteen more times and sold shares on sixteen occasions. The investor's estimated purchase price is $6.43 Million, resulting in a loss of 28%.